Still have questions?

If you have been prescribed
an Actelion medicine
and have questions,

call 1-866-ACTELION
(1-866-228-3546).

A Case Manager is available
to assist you Mon-Fri,
8 am-8 pm ET.

Spanish speakers and
other language services
are available.

VELETRI® (epoprostenol) for Injection Patient Resources

The following resources are designed to help you as you start treatment with VELETRI. You will also find common questions and answers about Actelion Pathways® and VELETRI.

More information and downloads are available at VELETRI.com.

Remember, your healthcare team should always be your first point of contact when you have questions about your health and your treatment.

Frequently Asked Questions (FAQs)

Actelion Pathways provides you with support and services, including benefits verification.

Actelion provides a wide range of support and services through Actelion Pathways. If you choose to enroll, your Actelion Pathways Case Manager will call you to:

  • Help answer your questions about filling your prescription
  • Coordinate with your healthcare provider and specialty pharmacy to help get you your medicine
  • Inform you of financial assistance programs based on your eligibility

The assistance of Actelion Pathways and Case Managers is available at no cost to patients taking VELETRI.

Enroll today. Call an Actelion Pathways Case Manager at 1-866-ACTELION (1-866-228-3546), Mon-Fri, 8 am-8 pm ET.

Spanish speakers and other language services are available.

Your Actelion Pathways Case Manager may be able to help. Call 1-866-ACTELION (1-866-228-3546), Mon-Fri, 8 am-8 pm ET to speak to a Case Manager.

Spanish speakers and other language services are available.

To learn about the basic steps to getting an Actelion medicine, download and review Steps to Getting Your Medicine.

Actelion medicines are available by mail from a specialty pharmacy. This is a pharmacy that can ship certain medicines directly to your home.

Learn about Working With a Specialty Pharmacy.

When your prescription is submitted to a specialty pharmacy, you will receive a call to:

  • Coordinate with your doctor and insurance company to find out if you have coverage for your medicine and explore financial assistance options
  • Arrange delivery of your medicine
  • Schedule your nurse visit

Each month, you will get a call from your specialty pharmacy to:

  • Confirm your order
  • Arrange delivery of your medicine

When your medicine is shipped, it will:

  • Be delivered to your home, unless you have made other arrangements
  • Need someone at home to sign for the package. Your specialty pharmacy will confirm this when they call to arrange delivery

Your insurance provider will need to gather information about your condition and your treatment before covering VELETRI. Sometimes, all their questions are answered at the time of prescription. They may also need more information, including:

  • Diagnostic test results, such as the numbers from your right heart catheterization (RHC)
  • Additional test results, including acute vasoreactivity testing or 6-minute walk distance (6MWD)
  • Details on past treatments you and your healthcare team have tried
  • Information missing from your prescription forms

There are programs available that can help you pay for VELETRI, if you are eligible:

  • Patient Assistance Program (PAP)—A yearly program that helps uninsured and underinsured patients receive medicine at no cost. Contact an Actelion Pathways Case Manager to learn more
  • Independent foundations—There may be support available from independent third-party patient support foundations. An Actelion Pathways Case Manager can provide general information about resources

There are independent organizations that can provide you with additional support and information:

  • The Pulmonary Hypertension Association is dedicated to increasing awareness and advocacy by providing information about PAH to both physicians and patients. Visit them online
  • The Scleroderma Foundation offers a site for scleroderma patients, caregivers, and family members—dedicated to support, education, and research. Visit their website to learn more

Find out more in Finding Support and Financial Assistance and by speaking with a Case Manager.

What is the most important information I should know about VELETRI?

It is important to use VELETRI as directed by your doctor. VELETRI should be used only with Sterile Water for Injection, USP, or Sodium Chloride 0.9% Injection, USP. Do not mix VELETRI with other intravenous medications. Each vial is for single use only; discard any unused medication. Use at room temperature (77°F/25°C). Do not expose VELETRI to direct sunlight.

See More

What is VELETRI® (epoprostenol)
for Injection?

VELETRI is a prescription medicine that is given intravenously (in a vein). It is used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH) (WHO Group 1), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. VELETRI may improve your ability to exercise as measured by how far you can walk in 6 minutes (6-minute walk test).

What is the most important information I should know about
VELETRI?

It is important to use VELETRI as directed by your doctor. VELETRI should be used only with Sterile Water for Injection, USP, or Sodium Chloride 0.9% Injection, USP. Do not mix VELETRI with other intravenous medications. Each vial is for single use only; discard any unused medication. Use at room temperature (77°F/25°C). Do not expose VELETRI to direct sunlight.

When you take epoprostenol for the first time, you must be in a setting (hospital or clinic) where you can be monitored for any serious side effects or in case of emergency. Your blood pressure and heart rate should also be monitored with any dose changes. If you are taking VELETRI, your doctor may prescribe another kind of medicine used to prevent blood clots. It is the use of these medications concomitantly (in combination) with VELETRI that may potentially cause an increase in the risk of bleeding.

Sudden and dramatic changes in dose may lead to unstable blood pressure, a return of pulmonary hypertension symptoms, or fatal low blood pressure (hypotension). Do not stop using VELETRI without first talking to your doctor.

To reduce the risk of infection in the bloodstream, it is important to know how to properly care for the catheter and infusion pump.

What are the possible side effects of VELETRI?

You may have side effects at the start of treatment or with dose increases. The most common side effects seen in at least 1% of patients were flushing, headache, nausea/vomiting, low blood pressure, anxiety/nervousness, chest pain, dizziness, slow heartbeat, abdominal pain, pain in the muscles and/or ligaments and bones, shortness of breath, back pain, sweating, upset stomach, numbness/increased sensitivity, and fast heartbeat.

The most common side effects in patients with PAH due to unidentified or hereditary factors with at least 10% difference between the group that received epoprostenol and the group that received conventional therapy alone were flu-like symptoms, fast heartbeat, flushing, diarrhea, nausea/vomiting, jaw pain, pain in the muscles and/or ligaments and bones, anxiety/nervousness, dizziness, headache, and numbness/increased sensitivity/tingling.

See More

What is VELETRI® (epoprostenol)
for Injection?

VELETRI is a prescription medicine that is given intravenously (in a vein). It is used to treat adults with certain kinds of severe pulmonary arterial hypertension (PAH) (WHO Group 1), a condition in which blood pressure is too high in the blood vessels between the heart and the lungs. VELETRI may improve your ability to exercise as measured by how far you can walk in 6 minutes (6-minute walk test).

Studies showing VELETRI is effective included mainly patients with NYHA Functional Class III-IV PAH. In these patients, PAH was caused by unidentified or hereditary factors or connective tissue disease.

Who should not take VELETRI?

VELETRI should not be used if you have heart failure due to severe left heart disease, if you develop fluid in the lungs (pulmonary edema) when starting therapy, or if you are allergic to epoprostenol.

Some medications may interact with VELETRI. Please talk to your doctor about all of your medications.

The most common side effects in patients with PAH due to connective tissue disease with at least 10% difference between the group that received epoprostenol and the group that received conventional therapy alone were flushing, low blood pressure, lack of appetite, nausea/vomiting, diarrhea, jaw pain, neck/joint pain, headache, skin ulcer, and rash.

Talk to your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of VELETRI. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information.