Contact a Case Manager for assistance

at 1-866-ACTELION
(1-866-228-3546).

Mon-Fri, 8 am-8 pm ET.

Support and Financial Assistance for OPSUMIT® (macitentan)

If you have insurance coverage when OPSUMIT is first prescribed, your healthcare team will submit your information to get your prescription paid for by your insurance plan. Sometimes, your insurance plan needs additional information. Alternatively, if you do not have insurance but need assistance to meet out-of-pocket costs, there may be financial assistance options available. In both cases, an Actelion Pathways® Case Manager can help with the process.

Connecting with financial assistance

There are several programs that can help you pay for OPSUMIT.

For all patients
The following program is open to all patients, regardless of their coverage
OPSUMIT Voucher Program Eligible patients over 18 may be able to obtain a 30-day supply of OPSUMIT at no charge by requesting it from the Actelion Pathways Case Manager during enrollment. This offer is only valid for the first 30-day supply of OPSUMIT.
Commercially insured
If you receive insurance through your employer or purchase it privately
Actelion Oral PAH Therapy Co-Pay Program* A savings program that lets eligible patients pay $5 per prescription fill per product. Contact an Actelion Pathways Case Manager for more information. Call 1-866-ACTELION (1-866-228-3546) Mon-Fri, 8 am-8 pm ET.*
Government insured
If you receive your medication through Medicare or other government-funded plans
Independent foundations There may be support available from independent third-party patient support foundations. An Actelion Pathways Case Manager can provide general information about resources.
Uninsured or underinsured
If you are uninsured or the cost of your medicine is covered by insurance, but you are unable to afford the out-of-pocket costs
Patient Assistance Program (PAP) A yearly program that helps you receive medicine at no cost. Contact an Actelion Pathways Case Manager to learn more.
Bridge Program (temporary patient assistance program) Offers 90 days of free drug coverage for patients when coverage is not immediately available (e.g., waiting for coverage to start, waiting for approval of prior authorization appeal, etc). Contact an Actelion Pathways Case Manager to learn more.

*Applies to patients who have provided consent to services offered by Actelion Pathways. The Actelion Oral PAH Therapy Co-Pay Program is only available for residents of the US and Puerto Rico who are 18 or older and have commercial health insurance with co-pay/co-insurance exceeding $5 per prescription fill per product. Patients ineligible for the Actelion Oral PAH Therapy Co-Pay Program include those enrolled in Medicare, Medicaid, VA/DoD (Tricare), the Indian Health Service, or any other federal- or state-funded healthcare program, or where prohibited by law. The Actelion Oral PAH Therapy Co-Pay Program is not prescription drug coverage or insurance. Actelion reserves the right to terminate or modify this program at any time or without notice. Other terms and conditions apply.

Additional support resources

The following organizations offer education and support to patients. Visit their websites for PAH information, news, and ideas about how to get involved with the PAH community.

Type of assistance Details Next steps
Education and advocacy The Pulmonary Hypertension Association is dedicated to increasing awareness and advocacy by providing information about PAH to both physicians and patients. Visit Pulmonary Hypertension Association online
Support and education The Scleroderma Foundation offers a site for scleroderma patients, caregivers, and family members—dedicated to support, education, and research. Visit Scleroderma Foundation online

Your Case Manager may need additional information from you at the start of treatment

When you speak with a Case Manager, they may ask for additional information including:

  • Details of your healthcare plan, including the name and contact information for the insurance company and your policy number
  • The name and contact information of your prescribing doctor (including the fax number)
  • If your initial claim is denied, your Case Manager may also need additional information from your healthcare team

If you change insurance plans or healthcare providers, speak with your healthcare team and a Case Manager to make sure you can continue your treatment in a timely manner.

Next: Find out about how your medicine can be delivered directly to your home in Working With a Specialty Pharmacy

Could you get more financial help with Medicare?

Find out if you qualify
for Extra Help
with Medicare.

What is the most important information about OPSUMIT® (macitentan)?

OPSUMIT can cause serious birth defects if taken during pregnancy.

  • Females must not be pregnant when starting OPSUMIT or get pregnant while taking OPSUMIT
  • Females who are able to get pregnant must have a negative pregnancy test before starting OPSUMIT, each month while taking OPSUMIT, and for 1 month after stopping OPSUMIT. Talk to your healthcare provider about your menstrual cycle. Your healthcare provider will decide when to do the pregnancy tests
    • Females who are able to get pregnant are females who have entered puberty, even if they have not started their menstrual period, and have a uterus, and have not gone through menopause (menopause means that you have not had a menstrual period for at least 12 months for natural reasons, or that you have had your ovaries removed)
    • Females who are not able to get pregnant are females who have not yet entered puberty, or do not have a uterus, or have gone through menopause (menopause means that you have not had a menstrual period for at least 12 months for natural reasons, or that you have had your ovaries removed) , or are infertile for other medical reasons and this infertility is permanent and cannot be reversed
See More

What is OPSUMIT?

OPSUMIT is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT can:

What is the most important information about OPSUMIT® (macitentan)?

OPSUMIT can cause serious birth defects if taken during pregnancy.

  • Females must not be pregnant when starting OPSUMIT or get pregnant while taking OPSUMIT
  • Females who are able to get pregnant must have a negative pregnancy test before starting OPSUMIT, each month while taking OPSUMIT, and for 1 month after stopping OPSUMIT. Talk to your healthcare provider about your menstrual cycle. Your healthcare provider will decide when to do the pregnancy tests
    • Females who are able to get pregnant are females who have entered puberty, even if they have not started their menstrual period, and have a uterus, and have not gone through menopause (menopause means that you have not had a menstrual period for at least 12 months for natural reasons, or that you have had your ovaries removed)
    • Females who are not able to get pregnant are females who have not yet entered puberty, or do not have a uterus, or have gone through menopause (menopause means that you have not had a menstrual period for at least 12 months for natural reasons, or that you have had your ovaries removed), or are infertile for other medical reasons and this infertility is permanent and cannot be reversed

Females who are able to get pregnant must use 2 acceptable forms of birth control during treatment with OPSUMIT and for 1 month after stopping OPSUMIT because the medicine may still be in the body. Females who have had a tubal sterilization, a progesterone implant, or have an IUD (intrauterine device) can use these methods alone without any other form of birth control.

  • Talk with your healthcare provider to find out about options for acceptable birth control that you may use to prevent pregnancy during treatment with OPSUMIT. See the OPSUMIT Medication Guide for acceptable birth control options
  • Do not have unprotected sex. Talk to your healthcare provider or pharmacist right away if you have unprotected sex or if you think your birth control has failed. Your healthcare provider may talk with you about using emergency birth control
  • Tell your healthcare provider right away if you miss a menstrual period or think you may be pregnant
See More

What is OPSUMIT?

OPSUMIT is a prescription medicine used to treat pulmonary arterial hypertension (PAH, WHO Group 1). PAH is high blood pressure in the arteries of your lungs. OPSUMIT can:

  • Improve your ability to exercise as measured by the 6-minute walk distance (6MWD). In a clinical study of mainly WHO FC II-III patients, those taking OPSUMIT walked, on average, 22 meters farther at Month 6 than patients not taking it
  • Improve some of your symptoms
  • Help slow down the progression of your disease. Disease progression included the need for injectable PAH medication or other worsening of PAH (decreased 6MWD, PAH symptoms getting worse, and the need for new PAH treatment)
  • Lower your chance of being hospitalized for PAH

It is not known if OPSUMIT is safe and effective in children.


If you are the parent or caregiver of a female child who started taking OPSUMIT before reaching puberty, you should check your child regularly to see if she is developing signs of puberty. Your child may reach puberty before having her first menstrual period. Talk to your healthcare provider if you think your child is developing signs of puberty or if you have any questions about the signs of puberty.

Females can only receive OPSUMIT through a restricted program called the OPSUMIT Risk Evaluation and Mitigation Strategy (REMS) Program. If you are a female who can get pregnant, you must talk to your healthcare provider, understand the benefits and risks of OPSUMIT, and agree to all of the instructions in the OPSUMIT REMS Program.

Males can receive OPSUMIT without taking part in the OPSUMIT REMS Program.

Who should not take OPSUMIT?

Do not take OPSUMIT if you are pregnant, plan to become pregnant, or become pregnant during treatment with OPSUMIT. OPSUMIT can cause serious birth defects. See "What is the most important information about OPSUMIT?" above.

Tell your healthcare provider about all your medical conditions and all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. OPSUMIT and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take an HIV medicine.

What should I avoid while taking OPSUMIT?

  • Do not get pregnant. OPSUMIT can cause serious birth defects. See "What is the most important information about OPSUMIT?" above. If you miss a menstrual period, or think you might be pregnant, call your healthcare provider right away
  • You should not breast-feed if you take OPSUMIT. It is not known if OPSUMIT passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take OPSUMIT

What are the possible side effects of OPSUMIT?

OPSUMIT can cause serious side effects, including:

  • Serious birth defects. See "What is the most important information about OPSUMIT?" above
  • Some medicines that are like OPSUMIT can cause liver problems. Your healthcare provider should do blood tests to check your liver before you start taking OPSUMIT. Tell your healthcare provider if you have any of the following symptoms of liver problems while taking OPSUMIT:
    • Nausea or vomiting
    • Pain in the upper right stomach
    • Tiredness
    • Loss of appetite
    • Your skin or the whites of your eyes turn yellow
    • Dark urine
    • Fever
    • Itching
  • Fluid retention could happen during the first weeks after starting OPSUMIT. Tell your doctor right away if you notice unusual weight gain or swelling in your ankles or legs. Your doctor will look for the cause
  • Low red blood cell levels (anemia) can happen with OPSUMIT treatment, usually during the first weeks after starting therapy with OPSUMIT. In some cases a blood transfusion may be needed, but this is not common. Your healthcare provider will do blood tests to check your red blood cells before you start OPSUMIT and may also need to do these tests while you are taking OPSUMIT
  • Sperm count reduction. Reduced sperm counts have been observed in some men taking a medicine similar to OPSUMIT, an effect which might impair their ability to father a child. Tell your healthcare provider if remaining fertile is important to you

The most common side effects of OPSUMIT are:

  • Stuffy nose or sore throat, irritation of the airways (bronchitis), headache, flu, and urinary tract infection

Tell your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of OPSUMIT. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information and Medication Guide, including an Important Warning about Serious Birth Defects.